- Civitavecchia, Italy (Rome) – Gateway to Rome and the Lazio region.
- Naples, Italy – Access to Pompeii, Amalfi Coast, and Capri.
- Palermo, Italy (Sicily) – Known for Sicilian culture and architecture.
- Valletta, Malta – Capital of Malta, rich in history and architecture.
- Messina, Italy – Located on the northeast tip of Sicily, near Taormina and Mount Etna.
- Sorrento, Italy – Overlooks the Bay of Naples and offers access to the Amalfi Coast.
- Cagliari, Italy (Sardinia) – Offers Sardinian culture and beaches.
- Trapani, Italy – Another Sicilian port known for its proximity to the Aegadian Islands and historic sites.